IMSAFE, in flight instruction and piloting, stands for a group of six variables that the FAA (US) considers measures of good fitness to fly:

I - Illness
M - Medication
S - Stress
A - Alcohol
F - Fatigue
E - Eating

Knowledge Management Space

FAA checklist
The six listed items with some further information.
This Wikipedia entry for IMSAFE simply repeats what the previous one says. However, it calls the attention to a common confusion, whereas E is defined as "Emotion" rather than as "Eating".
Tom HAMILTON's (1999) Checklist
It provides further explanation on each of above items. Although written for balloonists, the message equally applies to pilots.

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